<?xml version="1.0" encoding="UTF-8"?>
<channelml xmlns="http://morphml.org/channelml/schema"
xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
xmlns:meta="http://morphml.org/metadata/schema"
xsi:schemaLocation="http://morphml.org/channelml/schema http://www.neuroml.org/NeuroMLValidator/NeuroMLFiles/Schemata/v1.8.1/Level2/ChannelML_v1.8.1.xsd"
units="SI Units">
<meta:notes>A channel from Maex, R and De Schutter, E. Synchronization of Golgi and Granule Cell Firing in a
Detailed Network Model of the Cerebellar Granule Cell Layer</meta:notes>
<channel_type name="Gran_NaF_98">
<status value="stable">
<meta:comment>Verified equivalence of NEURON and GENESIS mapping to orig GENESIS impl from www.tnb.ua.ac.be</meta:comment>
<meta:comment>Updated to post v1.7.3 new ChannelML format</meta:comment>
<meta:issue>Quite a small dt (~0.001 ms) is needed to give matching NEURON/GENESIS results for a compartment with just
this channel (and a leak current)</meta:issue>
<meta:contributor>
<meta:name>Padraig Gleeson</meta:name>
</meta:contributor>
</status>
<meta:notes>Fast inactivating Na+ channel</meta:notes>
<meta:authorList>
<meta:modelAuthor>
<meta:name>Maex, R.</meta:name>
</meta:modelAuthor>
<meta:modelAuthor>
<meta:name>De Schutter, E.</meta:name>
</meta:modelAuthor>
<meta:modelTranslator>
<meta:name>Padraig Gleeson</meta:name>
<meta:institution>UCL</meta:institution>
<meta:email>p.gleeson - at - ucl.ac.uk</meta:email>
</meta:modelTranslator>
</meta:authorList>
<meta:publication>
<meta:fullTitle>Maex, R and De Schutter, E.
Synchronization of Golgi and Granule Cell Firing in a Detailed Network Model of the
cerebellar Granule Cell Layer. J Neurophysiol, Nov 1998; 80: 2521 - 2537</meta:fullTitle>
<meta:pubmedRef>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9819260&dopt=Abstract</meta:pubmedRef>
</meta:publication>
<meta:neuronDBref>
<meta:modelName>Na channels</meta:modelName>
<meta:uri>http://senselab.med.yale.edu/senselab/NeuronDB/channelGene2.htm#table2</meta:uri>
</meta:neuronDBref>
<current_voltage_relation cond_law="ohmic" ion="na" default_gmax="546.301" default_erev="0.055">
<q10_settings q10_factor="3" experimental_temp="17.350264793"/>
<offset value="0.010"/>
<gate name="m" instances="3">
<closed_state id="m0"/>
<open_state id="m"/>
<transition name="alpha" from="m0" to="m" expr_form="exponential" rate="1500" scale="0.012345679" midpoint="-0.039" />
<transition name="beta" from="m" to="m0" expr_form="exponential" rate="1500" scale="-0.0151515" midpoint="-0.039" />
<time_course name="tau" from="m0" to="m" expr_form="generic" expr="1/(alpha + beta) < 0.00005 ? 0.00005 : 1/(alpha + beta)" />
</gate>
<gate name="h" instances="1">
<closed_state id="h0"/>
<open_state id="h"/>
<transition name="alpha" from="h0" to="h" expr_form="exponential" rate="120" scale="-0.01123596" midpoint="-0.05" />
<transition name="beta" from="h" to="h0" expr_form="exponential" rate="120" scale="0.01123596" midpoint="-0.05" />
<time_course name="tau" from="h0" to="h" expr_form="generic" expr="1/(alpha + beta) < 0.000225 ? 0.000225 : 1/(alpha + beta)" />
</gate>
</current_voltage_relation>
<!-- Adding extra table divs due to discontinuity in tau-->
<impl_prefs>
<table_settings max_v="0.1" min_v="-0.1" table_divisions="4000"/>
</impl_prefs>
</channel_type>
</channelml>
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